Evaluation of preoperative criteria used to predict lymph node metastasis in endometrial cancer
Identifieur interne : 005D23 ( Main/Exploration ); précédent : 005D22; suivant : 005D24Evaluation of preoperative criteria used to predict lymph node metastasis in endometrial cancer
Auteurs : Seung-Su Han [Corée du Sud] ; Sang Hoon Lee [Corée du Sud] ; Dong Ho Kim [Corée du Sud] ; Jae Weon Kim [Corée du Sud] ; Noh-Hyun Park [Corée du Sud] ; Soon-Beom Kang [Corée du Sud] ; Yong Sang Song [Corée du Sud]Source :
- Acta Obstetricia et Gynecologica Scandinavica [ 0001-6349 ] ; 2010-02.
Abstract
Objective. To evaluate whether we could accurately predict lymph node (LN) metastasis with preoperative tests in endometrial cancer. Design. Retrospective study. Setting. Seoul National University Hospital, South Korea. Population. Three hundred patients with endometrial cancer who underwent surgical staging including lymphadenectomy between January 1999 and July 2007. Methods. We reviewed the medical records of 300 patients with endometrial cancer. The preoperative factors used to predict LN metastasis were as follows: old age (≥55 years), serum CA‐125 level [level ≥ 20 U/mL (if age < 50 years), level ≥ 28 U/mL (if age ≥ 50 years)], non‐endometrioid histologic type and Grade 3, metastatic LN assessed by pelvic MRI or CT, and deep myometrial invasion assessed by pelvic MRI only. Logistic regression analysis was used to determine the significant predictive factors. Main outcome measures. Sensitivity/specificity and false positive/negative rates. Results. Thirty patients had LN metastasis. Although LN evaluation by pelvic MRI or CT and high CA‐125 level were the significant independent predictors for LN metastasis, the sensitivity/specificity and false positive/negative rates for LN metastasis by these two combined preoperative tests were 86.7%/71.4% and 68.7%/2.7%, respectively. However, the sensitivity/specificity and false positive/negative rates for LN metastasis by six combined preoperative tests were 100%/28.9% and 84.6%/0%, respectively. Conclusions. The six combined preoperative tests are useful in selecting patients without LN metastasis in endometrial cancer. Lymphadenectomy could be avoided in about 29% of patients with endometrial cancer who have no LN metastasis by using six combined preoperative tests.
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DOI: 10.3109/00016340903370114
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Sud</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Acta Obstetricia et Gynecologica Scandinavica</title><title level="j" type="alt">ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA</title><idno type="ISSN">0001-6349</idno><idno type="eISSN">1600-0412</idno><imprint><biblScope unit="vol">89</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="168">168</biblScope><biblScope unit="page" to="174">174</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-02">2010-02</date></imprint><idno type="ISSN">0001-6349</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6349</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective. To evaluate whether we could accurately predict lymph node (LN) metastasis with preoperative tests in endometrial cancer. Design. Retrospective study. Setting. Seoul National University Hospital, South Korea. Population. Three hundred patients with endometrial cancer who underwent surgical staging including lymphadenectomy between January 1999 and July 2007. Methods. We reviewed the medical records of 300 patients with endometrial cancer. The preoperative factors used to predict LN metastasis were as follows: old age (≥55 years), serum CA‐125 level [level ≥ 20 U/mL (if age < 50 years), level ≥ 28 U/mL (if age ≥ 50 years)], non‐endometrioid histologic type and Grade 3, metastatic LN assessed by pelvic MRI or CT, and deep myometrial invasion assessed by pelvic MRI only. Logistic regression analysis was used to determine the significant predictive factors. Main outcome measures. Sensitivity/specificity and false positive/negative rates. Results. Thirty patients had LN metastasis. Although LN evaluation by pelvic MRI or CT and high CA‐125 level were the significant independent predictors for LN metastasis, the sensitivity/specificity and false positive/negative rates for LN metastasis by these two combined preoperative tests were 86.7%/71.4% and 68.7%/2.7%, respectively. However, the sensitivity/specificity and false positive/negative rates for LN metastasis by six combined preoperative tests were 100%/28.9% and 84.6%/0%, respectively. Conclusions. The six combined preoperative tests are useful in selecting patients without LN metastasis in endometrial cancer. Lymphadenectomy could be avoided in about 29% of patients with endometrial cancer who have no LN metastasis by using six combined preoperative tests.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Han, Seung U" sort="Han, Seung U" uniqKey="Han S" first="Seung-Su" last="Han">Seung-Su Han</name></region><name sortKey="Kang, Soon Eom" sort="Kang, Soon Eom" uniqKey="Kang S" first="Soon-Beom" last="Kang">Soon-Beom Kang</name><name sortKey="Kang, Soon Eom" sort="Kang, Soon Eom" uniqKey="Kang S" first="Soon-Beom" last="Kang">Soon-Beom Kang</name><name sortKey="Kim, Dong Ho" sort="Kim, Dong Ho" uniqKey="Kim D" first="Dong Ho" last="Kim">Dong Ho Kim</name><name sortKey="Kim, Jae Weon" sort="Kim, Jae Weon" uniqKey="Kim J" first="Jae Weon" last="Kim">Jae Weon Kim</name><name sortKey="Kim, Jae Weon" sort="Kim, Jae Weon" uniqKey="Kim J" first="Jae Weon" last="Kim">Jae Weon Kim</name><name sortKey="Lee, Sang Hoon" sort="Lee, Sang Hoon" uniqKey="Lee S" first="Sang Hoon" last="Lee">Sang Hoon Lee</name><name sortKey="Park, Noh Yun" sort="Park, Noh Yun" uniqKey="Park N" first="Noh-Hyun" last="Park">Noh-Hyun Park</name><name sortKey="Park, Noh Yun" sort="Park, Noh Yun" uniqKey="Park N" first="Noh-Hyun" last="Park">Noh-Hyun Park</name><name sortKey="Song, Yong Sang" sort="Song, Yong Sang" uniqKey="Song Y" first="Yong Sang" last="Song">Yong Sang Song</name><name sortKey="Song, Yong Sang" sort="Song, Yong Sang" uniqKey="Song Y" first="Yong Sang" last="Song">Yong Sang Song</name><name sortKey="Song, Yong Sang" sort="Song, Yong Sang" uniqKey="Song Y" first="Yong Sang" last="Song">Yong Sang Song</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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